{"id":1293,"date":"2024-04-23T16:15:04","date_gmt":"2024-04-23T08:15:04","guid":{"rendered":"https:\/\/www.k-15.cn\/index.php\/archives\/1293"},"modified":"2024-04-23T16:15:04","modified_gmt":"2024-04-23T08:15:04","slug":"%e9%86%8b%e9%85%b8%e6%b0%a2%e5%8c%96%e5%8f%af%e7%9a%84%e6%9d%be","status":"publish","type":"post","link":"https:\/\/www.k-15.cn\/index.php\/archives\/1293","title":{"rendered":"\u918b\u9178\u6c22\u5316\u53ef\u7684\u677e"},"content":{"rendered":"<p>    \t\t\t\t\t\t<img decoding=\"async\" src=\"http:\/\/staticv5.basechem.org\/img\/tupu\/old\/6f59035a930c4e0faedf476e39805301.gif\" alt=\"\u918b\u9178\u6c22\u5316\u53ef\u7684\u677e\u7ed3\u6784\u5f0f\"><\/p>\n<p>\u7ed3\u6784\u5f0f<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">\u7269\u7ade\u7f16\u53f7<\/th>\n<td>0134<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u5206\u5b50\u5f0f<\/th>\n<td>C23H32O6<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u5206\u5b50\u91cf<\/th>\n<td>404.5<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6807\u7b7e<\/th>\n<td>\n<p>                        \u6c22\u5316\u53ef\u7684\u677e-21-\u918b\u9178\u916f,<\/p>\n<p>                        \u918b\u9178\u6c22\u5316\u53ef\u7684\u677e,<\/p>\n<p>                        \u6c22\u5316\u53ef\u7684\u677e,<\/p>\n<p>                        \u5f02\u73af\u78f7\u9170\u80fa,<\/p>\n<p>                        \u6c22\u5316\u76ae\u8d28\u916e,<\/p>\n<p>                        \u6c22\u5316\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20,<\/p>\n<p>                        21-\u918b\u9178\u6c22\u5316\u53ef\u7684\u677e,<\/p>\n<p>                        Cortisol acetate,<\/p>\n<p>                        Hydrocortisone-21-acetate,<\/p>\n<p>                        Cortisol 21-acetate,<\/p>\n<p>                        21-Acetoxy-4-pregnene-11b,17a-diol-3,20-dione,<\/p>\n<p>                        17-\u03b1-Hydroxycorticosterone acetate,<\/p>\n<p>                        17-Hydroxycorticosterone 21-acetate,<\/p>\n<p>                         21-Acetoxy-4-pregnene-11\u03b2,<\/p>\n<p>                        17\u03b1-diol-3,20-dione, 4-Pregnene-11\u03b2,<\/p>\n<p>                        17\u03b1,21-triol-3,20-dione 21-acetate, 11\u03b2,<\/p>\n<p>                        \u6fc0\u7d20,<\/p>\n<p>                        \u6297\u98ce\u6e7f\u836f,<\/p>\n<p>                        \u6297\u708e\u836f<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">\u7f16\u53f7\u7cfb\u7edf<\/a><\/li>\n<li><a href=\"#wx\">\u7269\u6027\u6570\u636e<\/a><\/li>\n<li><a href=\"#dl\">\u6bd2\u7406\u5b66\u6570\u636e<\/a><\/li>\n<li><a href=\"#st\">\u751f\u6001\u5b66\u6570\u636e<\/a><\/li>\n<li><a href=\"#fz\">\u5206\u5b50\u7ed3\u6784\u6570\u636e<\/a><\/li>\n<li><a href=\"#js\">\u8ba1\u7b97\u5316\u5b66\u6570\u636e<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                    <a href=\"\" class=\"dropdown-toggle\" data-toggle=\"dropdown\">\u66f4\u591a <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">\u6027\u8d28\u4e0e\u7a33\u5b9a\u6027<\/a><\/li>\n<li><a href=\"#zc\">\u8d2e\u5b58\u65b9\u6cd5<\/a><\/li>\n<li><a href=\"#hc\">\u5408\u6210\u65b9\u6cd5<\/a><\/li>\n<li><a href=\"#yt\">\u7528\u9014<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">\u7f16\u53f7\u7cfb\u7edf<\/h2>\n<p><b>CAS\u53f7\uff1a<\/b>50-03-3<\/p>\n<p><b>MDL\u53f7\uff1a<\/b>MFCD00037714<\/p>\n<p><b>EINECS\u53f7\uff1a<\/b>200-004-4<\/p>\n<p><b>RTECS\u53f7\uff1a<\/b>GM8960000<\/p>\n<p><b>BRN\u53f7\uff1a<\/b>2066841<\/p>\n<p><b>PubChem\u53f7\uff1a<\/b>24895620<\/p>\n<h2 id=\"wx\">\u7269\u6027\u6570\u636e<\/h2>\n<p><p>1.&nbsp;&nbsp;&nbsp;&nbsp; \u6027\u72b6\uff1a\u767d\u8272\u6216\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u65e0\u6c14\u5473<\/p>\n<p>2.&nbsp;&nbsp;&nbsp;&nbsp; \u5bc6\u5ea6\uff08g\/mL,25\/4\u2103\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>3.&nbsp;&nbsp;&nbsp;&nbsp; \u76f8\u5bf9\u84b8\u6c7d\u5bc6\u5ea6\uff08g\/mL,\u7a7a\u6c14=1\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>4.&nbsp;&nbsp;&nbsp;&nbsp; \u7194\u70b9\uff08\u00baC\uff09\uff1a222-225\u00b0C\u3002<\/p>\n<p>5.&nbsp;&nbsp;&nbsp;&nbsp; \u6cb8\u70b9\uff08\u00baC,\u5e38\u538b\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>6.&nbsp;&nbsp;&nbsp;&nbsp; \u6cb8\u70b9\uff08\u00baC,5.2kPa\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>7.&nbsp;&nbsp;&nbsp;&nbsp; \u6298\u5c04\u7387\uff1a\u672a\u786e\u5b9a<\/p>\n<p>8.&nbsp;&nbsp;&nbsp;&nbsp; \u95ea\u70b9\uff08\u00baC\uff09\uff1a 223<\/p>\n<p>9.&nbsp;&nbsp; \u6bd4\u65cb\u5149\u5ea6\uff08\u00ba\uff09\uff1a[\u03b1]<sup>25<\/sup><sub>D<\/sub>+166\u00b0<\/p>\n<p>10.&nbsp;&nbsp; \u81ea\u71c3\u70b9\u6216\u5f15\u71c3\u6e29\u5ea6\uff08\u00baC\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>11.&nbsp;&nbsp; \u84b8\u6c14\u538b\uff08kPa,25\u00baC\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>12.&nbsp;&nbsp; \u9971\u548c\u84b8\u6c14\u538b\uff08kPa,60\u00baC\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>13.&nbsp;&nbsp; \u71c3\u70e7\u70ed\uff08KJ\/mol\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>14.&nbsp;&nbsp; \u4e34\u754c\u6e29\u5ea6\uff08\u00baC\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>15.&nbsp;&nbsp; \u4e34\u754c\u538b\u529b\uff08KPa\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>16.&nbsp;&nbsp; \u6cb9\u6c34\uff08\u8f9b\u9187\/\u6c34\uff09\u5206\u914d\u7cfb\u6570\u7684\u5bf9\u6570\u503c\uff1a\u672a\u786e\u5b9a<\/p>\n<p>17.&nbsp;&nbsp; \u7206\u70b8\u4e0a\u9650\uff08%,V\/V\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>18.&nbsp;&nbsp; \u7206\u70b8\u4e0b\u9650\uff08%,V\/V\uff09\uff1a\u672a\u786e\u5b9a<\/p>\n<p>19.&nbsp;&nbsp; \u6eb6\u89e3\u6027\uff1a\u672a\u786e\u5b9a<\/p>\n<\/p>\n<h2 id=\"dl\">\u6bd2\u7406\u5b66\u6570\u636e<\/h2>\n<p><p>\u6025\u6027\u6bd2\u6027\uff1a\u5927\u9f20\u76ae\u4e0bLDL0\uff1a 250 mg\/kg,\uff1b\u5c0f\u9f20\u8179\u8154LD50\uff1a2300 mg\/kg\uff1b\u5c0f\u9f20\u76ae\u4e0bLD50\uff1a45050 ug\/kg\u3002 <\/p>\n<p>2\u3001&nbsp; \u4e9a\u6025\u6027\u6bd2\u6027<\/p>\n<p>\u5927\u9f20\u76ae\u4e0b\u53e3\u7ecfTDL0\uff1a175 mg\/kg\/35D-I <\/p>\n<p>3\u3001&nbsp; \u81f4\u7578\u6027\uff1a\u5c0f\u9f20\u8bd5\u9a8c\uff1a60 mg\/kg\uff0cDNA\u7834\u574f;150mg\/kg\uff0c\u57fa\u56e0\u7a81\u53d8\u3002<\/p>\n<p>4\u3001&nbsp; \u751f\u6b96\u6bd2\u6027<\/p>\n<p>\u5927\u9f20\u53e3\u5f84TDLo\uff1a1 mg\/kg\uff0c\u80ce\u513f\u53d1\u80b2\u8fdf\u7f13\uff1b\u5927\u9f20\u53e3\u5f84TDLo\uff1a1500 mg\/kg\uff0c\u80ce\u513f\u6b7b\u4ea1\uff1b<\/p>\n<p>\u5927\u9f20\u8179\u8154TDLo\uff1a2 mg\/kg\uff0c\u80da\u80ce\u6b7b\u4ea1\uff1b\u5927\u9f20\u76ae\u4e0bTDLo\uff1a350 mg\/kg\uff0c\u80ce\u513f\u53d1\u80b2\u8fdf\u7f13<\/p>\n<p>\u5c0f\u9f20\u53e3\u5f84TDLo\uff1a125 mg\/kg\uff0c\u80ce\u513f\u53d1\u80b2\u8fdf\u7f13\uff1b\u5c0f\u9f20\u76ae\u4e0bTDLo\uff1a250 mg\/kg\uff0c\u80ce\u513f\u6b7b\u4ea1\uff1b<\/p>\n<p>\u5c0f\u9f20\u76ae\u4e0bTDLo\uff1a75 mg\/kg\uff0c\u80ce\u513f\u53d1\u80b2\u8fdf\u7f13\uff1b\u5c0f\u9f20\u76ae\u4e0bTDLo\uff1a84mg\/kg\uff0c\u80ce\u513f\u53d1\u80b2\u8fdf\u7f13<\/p>\n<p>\u5c0f\u9f20\u808c\u8089TDLo\uff1a64mg\/kg\uff0c\u5f71\u54cd\u4e0d\u5927\uff1b\u5c0f\u9f20\u808c\u8089TDLo\uff1a320mg\/kg\uff1b\u7578\u5f62<\/p>\n<p>\u5c0f\u9f20\u80a0\u9053TDLo\uff1a200 mg\/kg\uff1b<\/p>\n<p>\u5154\u5b50\u53e3\u5f84TDLo\uff1a: 13 mg\/kg <\/p>\n<p>\u732a\u808c\u8089TDLo \uff1a100 mg\/kg\n    \t<\/p>\n<h2 id=\"st\">\u751f\u6001\u5b66\u6570\u636e<\/h2>\n<p>\n    \t\t\u5176\u5b83\u6709\u5bb3\u4f5c\u7528\uff1a\u8be5\u7269\u8d28\u5bf9\u73af\u5883\u6709\u5371\u5bb3\uff0c\u5bf9\u6c34\u4f53\u5e94\u7ed9\u4e88\u7279\u522b\u6ce8\u610f\u3002\u4e3a\u6709\u5bb3\u7269\u54c1\u3002\n    \t<\/p>\n<h2 id=\"fz\">\u5206\u5b50\u7ed3\u6784\u6570\u636e<\/h2>\n<p><p>1\u3001&nbsp; \u6469\u5c14\u6298\u5c04\u7387\uff1a103.75<\/p>\n<p>2\u3001&nbsp; \u6469\u5c14\u4f53\u79ef\uff08cm<sup>3<\/sup>\/mol\uff09\uff1a318.1<\/p>\n<p>3\u3001&nbsp; \u7b49\u5f20\u6bd4\u5bb9\uff0890.2K\uff09\uff1a858.0<\/p>\n<p>4\u3001&nbsp; \u8868\u9762\u5f20\u529b\uff08dyne\/cm\uff09\uff1a52.8<\/p>\n<p>5\u3001&nbsp; \u6781\u5316\u7387\uff0810-24cm3\uff09\uff1a41.13<\/p>\n<\/p>\n<h2 id=\"js\">\u8ba1\u7b97\u5316\u5b66\u6570\u636e<\/h2>\n<p><p>1\u3001&nbsp; \u758f\u6c34\u53c2\u6570\u8ba1\u7b97\u53c2\u8003\u503c\uff08XlogP\uff09\uff1a2.2<\/p>\n<p>2\u3001&nbsp; \u6c22\u952e\u4f9b\u4f53\u6570\u91cf\uff1a2<\/p>\n<p>3\u3001&nbsp; \u6c22\u952e\u53d7\u4f53\u6570\u91cf\uff1a6<\/p>\n<p>4\u3001&nbsp; \u53ef\u65cb\u8f6c\u5316\u5b66\u952e\u6570\u91cf\uff1a4<\/p>\n<p>5\u3001&nbsp; \u4e92\u53d8\u5f02\u6784\u4f53\u6570\u91cf\uff1a10<\/p>\n<p>6\u3001&nbsp; \u62d3\u6251\u5206\u5b50\u6781\u6027\u8868\u9762\u79ef\uff08TPSA\uff09\uff1a101<\/p>\n<p>7\u3001&nbsp; \u91cd\u539f\u5b50\u6570\u91cf\uff1a29<\/p>\n<p>8\u3001&nbsp; \u8868\u9762\u7535\u8377\uff1a0<\/p>\n<p>9\u3001&nbsp; \u590d\u6742\u5ea6\uff1a786<\/p>\n<p>10\u3001&nbsp;&nbsp;&nbsp; \u540c\u4f4d\u7d20\u539f\u5b50\u6570\u91cf\uff1a0<\/p>\n<p>11\u3001&nbsp;&nbsp;&nbsp; \u786e\u5b9a\u539f\u5b50\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf\uff1a7<\/p>\n<p>12\u3001&nbsp;&nbsp;&nbsp; \u4e0d\u786e\u5b9a\u539f\u5b50\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf\uff1a0<\/p>\n<p>13\u3001&nbsp;&nbsp;&nbsp; \u786e\u5b9a\u5316\u5b66\u952e\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf\uff1a0<\/p>\n<p>14\u3001&nbsp;&nbsp;&nbsp; \u4e0d\u786e\u5b9a\u5316\u5b66\u952e\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf\uff1a0<\/p>\n<p>15\u3001&nbsp;&nbsp;&nbsp; \u5171\u4ef7\u952e\u5355\u5143\u6570\u91cf\uff1a1<\/p>\n<\/p>\n<h2 id=\"xz\">\u6027\u8d28\u4e0e\u7a33\u5b9a\u6027<\/h2>\n<p><p>\u767d\u8272\u6216\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u65e0\u6c14\u5473\u3002Mp218-221.5\u2103\uff1b \u6bd4\u65cb\u5149\u5ea6[\u03b1]25D+166\u00b0(\u4e8c\u5641\u70f7)\uff1b\u6eb6\u6db2\u5728240nm\u6ce2\u957f\u5904\u6709\u5927\u5438\u6536\u3002\u4e0d\u6eb6\u4e8e\u6c34\uff0c\u5fae\u6eb6\u4e8e(1\uff1a230)\u548c\u6c2f\u4eff(1\uff1a150)\uff0c\u96be\u6eb6\u4e8e\u3002<\/p>\n<\/p>\n<h2 id=\"zc\">\u8d2e\u5b58\u65b9\u6cd5<\/h2>\n<p>\n    \t\t0-6 \u00baC\u906e\u5149\uff0c\u5bc6\u5c01\u4fdd\u5b58\u3002\n    \t<\/p>\n<h2 id=\"hc\">\u5408\u6210\u65b9\u6cd5<\/h2>\n<p><p>\u91c7\u7528C3-C5\u7684\u8102\u80aa\u916e\u4f5c\u6eb6\u5242,\u52a0\u5165\u4e00\u5b9a\u91cf\u7684\u918b\u9178\u76d0,\u7531\u6c22\u5316\u53ef\u7684\u677e\u3001\u918b\u9178\u3001\u918b\u9150\u5408\u6210\u5236\u5f97\u3002<\/p>\n<\/p>\n<h2 id=\"yt\">\u7528\u9014<\/h2>\n<p><p>\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u98ce\u6e7f\u70ed\u3001\u75db\u98ce\u3001\u652f\u6c14\u7ba1\u54ee\u5598\u7b49\u3002\u9488\u5242\u7528\u4e8e\u7ed3\u6838\u6027\u6216\u5316\u8113\u6027\u8111\u819c\u708e\u3001\u7ed3\u6838\u6027\u80f8\u819c\u708e\u3001\u8113\u80f8\u3001\u5173\u8282\u708e\u3001\u8171\u9798\u708e\u3001\u808c\u8171\u52b3\u635f\u3001\u626d\u4f24\u3001\u7ed3\u8282\u6027\u75d2\u75b9\u3001\u6241\u5e73\u82d4\u85d3\u7b49\u3002\u6ef4\u773c\u5242\u7528\u4e8e\u5404\u79cd\u773c\u708e\u3002\u971c\u5242\u7528\u4e8e\u8fc7\u654f\u6027\u6216\u8102\u6ea2\u6027\u76ae\u708e\u3001\u7619\u75d2\u75c7\u7b49\u3002<\/p>\n<\/p>\n<p>    \t\u6269\u5c55\u9605\u8bfbhttps:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/N-N-Dimethylethanolamine-CAS108-01-0-2-Dimethylamineethanol.pdf<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.newtopchem.com\/archives\/40238<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.newtopchem.com\/archives\/category\/products\/page\/21<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.bdmaee.net\/wp-content\/uploads\/2021\/05\/2-6.jpg<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.newtopchem.com\/archives\/category\/products\/page\/146<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.bdmaee.net\/dabco-xd-104-dabco-tertiary-amine-catalyst-catalyst-xd-104\/<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/1-1.jpg<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.newtopchem.com\/archives\/44126<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.morpholine.org\/polyurethane-catalyst-1028\/<\/br>\u6269\u5c55\u9605\u8bfbhttps:\/\/www.morpholine.org\/2-dimethylamineethanol\/<\/br><\/p>\n","raw":"","protected":false},"excerpt":{"rendered":"<p>\u7ed3\u6784\u5f0f \u7269\u7ade\u7f16\u53f7 0134 \u5206\u5b50\u5f0f C23H32O6 \u5206\u5b50\u91cf 404.5 \u6807\u7b7e \u6c22\u5316\u53ef\u7684\u677e-21-\u918b\u9178\u916f, \u918b\u9178\u6c22\u5316\u53ef\u7684\u677e, \u6c22\u5316\u53ef\u7684\u677e, \u5f02\u73af\u78f7\u9170\u80fa, \u6c22\u5316\u76ae\u8d28\u916e, \u6c22\u5316\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20, 21-\u918b\u9178\u6c22\u5316\u53ef\u7684\u677e, Cortisol acetate, Hydrocortisone-21-acetate, Cortisol 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